Finding New Cell Wall Regulatory Genes in Populus trichocarpa Using Multiple Lines of Evidence.
Identifieur interne : 000963 ( Main/Exploration ); précédent : 000962; suivant : 000964Finding New Cell Wall Regulatory Genes in Populus trichocarpa Using Multiple Lines of Evidence.
Auteurs : Anna Furches [États-Unis] ; David Kainer [États-Unis] ; Deborah Weighill [États-Unis] ; Annabel Large [États-Unis] ; Piet Jones [États-Unis] ; Angelica M. Walker [États-Unis] ; Jonathon Romero [États-Unis] ; Joao Gabriel Felipe Machado Gazolla [États-Unis] ; Wayne Joubert [États-Unis] ; Manesh Shah [États-Unis] ; Jared Streich [États-Unis] ; Priya Ranjan [États-Unis] ; Jeremy Schmutz [États-Unis] ; Avinash Sreedasyam [États-Unis] ; David Macaya-Sanz [États-Unis] ; Nan Zhao [États-Unis] ; Madhavi Z. Martin [États-Unis] ; Xiaolan Rao [États-Unis] ; Richard A. Dixon [États-Unis] ; Stephen Difazio [États-Unis] ; Timothy J. Tschaplinski [États-Unis] ; Jin-Gui Chen [États-Unis] ; Gerald A. Tuskan [États-Unis] ; Daniel Jacobson [États-Unis]Source :
- Frontiers in plant science [ 1664-462X ] ; 2019.
Abstract
Understanding the regulatory network controlling cell wall biosynthesis is of great interest in Populus trichocarpa, both because of its status as a model woody perennial and its importance for lignocellulosic products. We searched for genes with putatively unknown roles in regulating cell wall biosynthesis using an extended network-based Lines of Evidence (LOE) pipeline to combine multiple omics data sets in P. trichocarpa, including gene coexpression, gene comethylation, population level pairwise SNP correlations, and two distinct SNP-metabolite Genome Wide Association Study (GWAS) layers. By incorporating validation, ranking, and filtering approaches we produced a list of nine high priority gene candidates for involvement in the regulation of cell wall biosynthesis. We subsequently performed a detailed investigation of candidate gene GROWTH-REGULATING FACTOR 9 (PtGRF9). To investigate the role of PtGRF9 in regulating cell wall biosynthesis, we assessed the genome-wide connections of PtGRF9 and a paralog across data layers with functional enrichment analyses, predictive transcription factor binding site analysis, and an independent comparison to eQTN data. Our findings indicate that PtGRF9 likely affects the cell wall by directly repressing genes involved in cell wall biosynthesis, such as PtCCoAOMT and PtMYB.41, and indirectly by regulating homeobox genes. Furthermore, evidence suggests that PtGRF9 paralogs may act as transcriptional co-regulators that direct the global energy usage of the plant. Using our extended pipeline, we show multiple lines of evidence implicating the involvement of these genes in cell wall regulatory functions and demonstrate the value of this method for prioritizing candidate genes for experimental validation.
DOI: 10.3389/fpls.2019.01249
PubMed: 31649710
PubMed Central: PMC6791931
Affiliations:
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Dixon</name><affiliation wicri:level="2"><nlm:affiliation>BioDiscovery Institute and Department of Biological Sciences, University of North Texas, Denton, TX, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>BioDiscovery Institute and Department of Biological Sciences, University of North Texas, Denton, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Difazio, Stephen" sort="Difazio, Stephen" uniqKey="Difazio S" first="Stephen" last="Difazio">Stephen Difazio</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biology, West Virginia University, Morgantown, WV, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, West Virginia University, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Tschaplinski, Timothy J" sort="Tschaplinski, Timothy J" uniqKey="Tschaplinski T" first="Timothy J" last="Tschaplinski">Timothy J. Tschaplinski</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Chen, Jin Gui" sort="Chen, Jin Gui" uniqKey="Chen J" first="Jin-Gui" last="Chen">Jin-Gui Chen</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Tuskan, Gerald A" sort="Tuskan, Gerald A" uniqKey="Tuskan G" first="Gerald A" last="Tuskan">Gerald A. Tuskan</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Jacobson, Daniel" sort="Jacobson, Daniel" uniqKey="Jacobson D" first="Daniel" last="Jacobson">Daniel Jacobson</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31649710</idno><idno type="pmid">31649710</idno><idno type="doi">10.3389/fpls.2019.01249</idno><idno type="pmc">PMC6791931</idno><idno type="wicri:Area/Main/Corpus">000648</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000648</idno><idno type="wicri:Area/Main/Curation">000648</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000648</idno><idno type="wicri:Area/Main/Exploration">000648</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Finding New Cell Wall Regulatory Genes in <i>Populus trichocarpa</i> Using Multiple Lines of Evidence.</title><author><name sortKey="Furches, Anna" sort="Furches, Anna" uniqKey="Furches A" first="Anna" last="Furches">Anna Furches</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Kainer, David" sort="Kainer, David" uniqKey="Kainer D" first="David" last="Kainer">David Kainer</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Weighill, Deborah" sort="Weighill, Deborah" uniqKey="Weighill D" first="Deborah" last="Weighill">Deborah Weighill</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Large, Annabel" sort="Large, Annabel" uniqKey="Large A" first="Annabel" last="Large">Annabel Large</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Oak Ridge Associated Universities (ORAU), Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Oak Ridge Associated Universities (ORAU), Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Jones, Piet" sort="Jones, Piet" uniqKey="Jones P" first="Piet" last="Jones">Piet Jones</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Walker, Angelica M" sort="Walker, Angelica M" uniqKey="Walker A" first="Angelica M" last="Walker">Angelica M. Walker</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Oak Ridge Associated Universities (ORAU), Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Oak Ridge Associated Universities (ORAU), Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Computer Science, Johns Hopkins University, Baltimore, MD, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Computer Science, Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Biology, Johns Hopkins University, Baltimore, MD, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Romero, Jonathon" sort="Romero, Jonathon" uniqKey="Romero J" first="Jonathon" last="Romero">Jonathon Romero</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Gazolla, Joao Gabriel Felipe Machado" sort="Gazolla, Joao Gabriel Felipe Machado" uniqKey="Gazolla J" first="Joao Gabriel Felipe Machado" last="Gazolla">Joao Gabriel Felipe Machado Gazolla</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Joubert, Wayne" sort="Joubert, Wayne" uniqKey="Joubert W" first="Wayne" last="Joubert">Wayne Joubert</name><affiliation wicri:level="2"><nlm:affiliation>Oak Ridge Leadership Computing Facility, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Oak Ridge Leadership Computing Facility, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Shah, Manesh" sort="Shah, Manesh" uniqKey="Shah M" first="Manesh" last="Shah">Manesh Shah</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Streich, Jared" sort="Streich, Jared" uniqKey="Streich J" first="Jared" last="Streich">Jared Streich</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Ranjan, Priya" sort="Ranjan, Priya" uniqKey="Ranjan P" first="Priya" last="Ranjan">Priya Ranjan</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Sciences, The University of Tennessee Institute of Agriculture, University of Tennessee, Knoxville, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Sciences, The University of Tennessee Institute of Agriculture, University of Tennessee, Knoxville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Schmutz, Jeremy" sort="Schmutz, Jeremy" uniqKey="Schmutz J" first="Jeremy" last="Schmutz">Jeremy Schmutz</name><affiliation wicri:level="2"><nlm:affiliation>Joint Genome Institute, Walnut Creek, CA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Joint Genome Institute, Walnut Creek, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>HudsonAlpha Institute for Biotechnology, Huntsville, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Sreedasyam, Avinash" sort="Sreedasyam, Avinash" uniqKey="Sreedasyam A" first="Avinash" last="Sreedasyam">Avinash Sreedasyam</name><affiliation wicri:level="2"><nlm:affiliation>HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>HudsonAlpha Institute for Biotechnology, Huntsville, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Macaya Sanz, David" sort="Macaya Sanz, David" uniqKey="Macaya Sanz D" first="David" last="Macaya-Sanz">David Macaya-Sanz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biology, West Virginia University, Morgantown, WV, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, West Virginia University, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Zhao, Nan" sort="Zhao, Nan" uniqKey="Zhao N" first="Nan" last="Zhao">Nan Zhao</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Sciences, The University of Tennessee Institute of Agriculture, University of Tennessee, Knoxville, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Sciences, The University of Tennessee Institute of Agriculture, University of Tennessee, Knoxville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Martin, Madhavi Z" sort="Martin, Madhavi Z" uniqKey="Martin M" first="Madhavi Z" last="Martin">Madhavi Z. Martin</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Rao, Xiaolan" sort="Rao, Xiaolan" uniqKey="Rao X" first="Xiaolan" last="Rao">Xiaolan Rao</name><affiliation wicri:level="2"><nlm:affiliation>BioDiscovery Institute and Department of Biological Sciences, University of North Texas, Denton, TX, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>BioDiscovery Institute and Department of Biological Sciences, University of North Texas, Denton, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Dixon, Richard A" sort="Dixon, Richard A" uniqKey="Dixon R" first="Richard A" last="Dixon">Richard A. Dixon</name><affiliation wicri:level="2"><nlm:affiliation>BioDiscovery Institute and Department of Biological Sciences, University of North Texas, Denton, TX, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>BioDiscovery Institute and Department of Biological Sciences, University of North Texas, Denton, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Difazio, Stephen" sort="Difazio, Stephen" uniqKey="Difazio S" first="Stephen" last="Difazio">Stephen Difazio</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biology, West Virginia University, Morgantown, WV, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, West Virginia University, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Tschaplinski, Timothy J" sort="Tschaplinski, Timothy J" uniqKey="Tschaplinski T" first="Timothy J" last="Tschaplinski">Timothy J. Tschaplinski</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Chen, Jin Gui" sort="Chen, Jin Gui" uniqKey="Chen J" first="Jin-Gui" last="Chen">Jin-Gui Chen</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Tuskan, Gerald A" sort="Tuskan, Gerald A" uniqKey="Tuskan G" first="Gerald A" last="Tuskan">Gerald A. Tuskan</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Jacobson, Daniel" sort="Jacobson, Daniel" uniqKey="Jacobson D" first="Daniel" last="Jacobson">Daniel Jacobson</name><affiliation wicri:level="2"><nlm:affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><series><title level="j">Frontiers in plant science</title><idno type="ISSN">1664-462X</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Understanding the regulatory network controlling cell wall biosynthesis is of great interest in <i>Populus trichocarpa</i>, both because of its status as a model woody perennial and its importance for lignocellulosic products. We searched for genes with putatively unknown roles in regulating cell wall biosynthesis using an extended network-based Lines of Evidence (LOE) pipeline to combine multiple omics data sets in <i>P. trichocarpa</i>, including gene coexpression, gene comethylation, population level pairwise SNP correlations, and two distinct SNP-metabolite Genome Wide Association Study (GWAS) layers. By incorporating validation, ranking, and filtering approaches we produced a list of nine high priority gene candidates for involvement in the regulation of cell wall biosynthesis. We subsequently performed a detailed investigation of candidate gene GROWTH-REGULATING FACTOR 9 (<i>PtGRF9</i>). To investigate the role of <i>PtGRF9</i> in regulating cell wall biosynthesis, we assessed the genome-wide connections of <i>PtGRF9</i> and a paralog across data layers with functional enrichment analyses, predictive transcription factor binding site analysis, and an independent comparison to eQTN data. Our findings indicate that PtGRF9 likely affects the cell wall by directly repressing genes involved in cell wall biosynthesis, such as <i>PtCCoAOMT</i> and <i>PtMYB.41</i>, and indirectly by regulating homeobox genes. Furthermore, evidence suggests that <i>PtGRF9</i> paralogs may act as transcriptional co-regulators that direct the global energy usage of the plant. Using our extended pipeline, we show multiple lines of evidence implicating the involvement of these genes in cell wall regulatory functions and demonstrate the value of this method for prioritizing candidate genes for experimental validation.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">31649710</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1664-462X</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><PubDate><Year>2019</Year></PubDate></JournalIssue><Title>Frontiers in plant science</Title><ISOAbbreviation>Front Plant Sci</ISOAbbreviation></Journal><ArticleTitle>Finding New Cell Wall Regulatory Genes in <i>Populus trichocarpa</i> Using Multiple Lines of Evidence.</ArticleTitle><Pagination><MedlinePgn>1249</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fpls.2019.01249</ELocationID><Abstract><AbstractText>Understanding the regulatory network controlling cell wall biosynthesis is of great interest in <i>Populus trichocarpa</i>, both because of its status as a model woody perennial and its importance for lignocellulosic products. We searched for genes with putatively unknown roles in regulating cell wall biosynthesis using an extended network-based Lines of Evidence (LOE) pipeline to combine multiple omics data sets in <i>P. trichocarpa</i>, including gene coexpression, gene comethylation, population level pairwise SNP correlations, and two distinct SNP-metabolite Genome Wide Association Study (GWAS) layers. By incorporating validation, ranking, and filtering approaches we produced a list of nine high priority gene candidates for involvement in the regulation of cell wall biosynthesis. We subsequently performed a detailed investigation of candidate gene GROWTH-REGULATING FACTOR 9 (<i>PtGRF9</i>). To investigate the role of <i>PtGRF9</i> in regulating cell wall biosynthesis, we assessed the genome-wide connections of <i>PtGRF9</i> and a paralog across data layers with functional enrichment analyses, predictive transcription factor binding site analysis, and an independent comparison to eQTN data. Our findings indicate that PtGRF9 likely affects the cell wall by directly repressing genes involved in cell wall biosynthesis, such as <i>PtCCoAOMT</i> and <i>PtMYB.41</i>, and indirectly by regulating homeobox genes. Furthermore, evidence suggests that <i>PtGRF9</i> paralogs may act as transcriptional co-regulators that direct the global energy usage of the plant. Using our extended pipeline, we show multiple lines of evidence implicating the involvement of these genes in cell wall regulatory functions and demonstrate the value of this method for prioritizing candidate genes for experimental validation.</AbstractText><CopyrightInformation>Copyright © 2019 Furches, Kainer, Weighill, Large, Jones, Walker, Romero, Gazolla, Joubert, Shah, Streich, Ranjan, Schmutz, Sreedasyam, Macaya-Sanz, Zhao, Martin, Rao, Dixon, DiFazio, Tschaplinski, Chen, Tuskan and Jacobson.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Furches</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kainer</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weighill</LastName><ForeName>Deborah</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Large</LastName><ForeName>Annabel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Oak Ridge Associated Universities (ORAU), Oak Ridge, TN, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Piet</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walker</LastName><ForeName>Angelica M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Oak Ridge Associated Universities (ORAU), Oak Ridge, TN, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Computer Science, Johns Hopkins University, Baltimore, MD, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biology, Johns Hopkins University, Baltimore, MD, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romero</LastName><ForeName>Jonathon</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gazolla</LastName><ForeName>Joao Gabriel Felipe Machado</ForeName><Initials>JGFM</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joubert</LastName><ForeName>Wayne</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Oak Ridge Leadership Computing Facility, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shah</LastName><ForeName>Manesh</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Streich</LastName><ForeName>Jared</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ranjan</LastName><ForeName>Priya</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Plant Sciences, The University of Tennessee Institute of Agriculture, University of Tennessee, Knoxville, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmutz</LastName><ForeName>Jeremy</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Joint Genome Institute, Walnut Creek, CA, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sreedasyam</LastName><ForeName>Avinash</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Macaya-Sanz</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biology, West Virginia University, Morgantown, WV, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Nan</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Plant Sciences, The University of Tennessee Institute of Agriculture, University of Tennessee, Knoxville, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Madhavi Z</ForeName><Initials>MZ</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rao</LastName><ForeName>Xiaolan</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>BioDiscovery Institute and Department of Biological Sciences, University of North Texas, Denton, TX, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dixon</LastName><ForeName>Richard A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>BioDiscovery Institute and Department of Biological Sciences, University of North Texas, Denton, TX, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>DiFazio</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biology, West Virginia University, Morgantown, WV, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tschaplinski</LastName><ForeName>Timothy J</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Jin-Gui</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tuskan</LastName><ForeName>Gerald A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacobson</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Biosciences Division, and The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, TN, United States.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>10</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Plant Sci</MedlineTA><NlmUniqueID>101568200</NlmUniqueID><ISSNLinking>1664-462X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Genome Wide Association Study</Keyword><Keyword MajorTopicYN="N">Populus trichocarpa</Keyword><Keyword MajorTopicYN="N">candidate gene identification</Keyword><Keyword MajorTopicYN="N">cell wall</Keyword><Keyword MajorTopicYN="N">lines of evidence</Keyword><Keyword MajorTopicYN="N">multi-omic</Keyword><Keyword MajorTopicYN="N">network analysis</Keyword><Keyword MajorTopicYN="N">regulation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>02</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>09</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>10</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>10</Month><Day>28</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31649710</ArticleId><ArticleId IdType="doi">10.3389/fpls.2019.01249</ArticleId><ArticleId IdType="pmc">PMC6791931</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>PLoS One. 2011 Feb 28;6(2):e17458</Citation><ArticleIdList><ArticleId IdType="pubmed">21386988</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2015 Jan 15;31(2):166-9</Citation><ArticleIdList><ArticleId IdType="pubmed">25260700</ArticleId></ArticleIdList></Reference><Reference><Citation>C R Biol. 2010 Apr;333(4):371-81</Citation><ArticleIdList><ArticleId IdType="pubmed">20371112</ArticleId></ArticleIdList></Reference><Reference><Citation>Tree Physiol. 2014 Nov;34(11):1289-300</Citation><ArticleIdList><ArticleId IdType="pubmed">24728296</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Biol. 2012 Jul 10;22(13):1207-12</Citation><ArticleIdList><ArticleId IdType="pubmed">22704988</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Mol Biol. 2006 Aug;61(6):917-32</Citation><ArticleIdList><ArticleId IdType="pubmed">16927204</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Cell. 2001 Nov;13(11):2455-70</Citation><ArticleIdList><ArticleId IdType="pubmed">11701881</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2015 Jan 29;517(7536):571-5</Citation><ArticleIdList><ArticleId IdType="pubmed">25533953</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Cell. 2004 Sep;16(9):2278-92</Citation><ArticleIdList><ArticleId IdType="pubmed">15316113</ArticleId></ArticleIdList></Reference><Reference><Citation>New Phytol. 2012 Apr;194(1):102-15</Citation><ArticleIdList><ArticleId IdType="pubmed">22236040</ArticleId></ArticleIdList></Reference><Reference><Citation>New Phytol. 2013 Nov;200(3):727-42</Citation><ArticleIdList><ArticleId IdType="pubmed">23889128</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Mol Biol. 2013 May;82(1-2):71-83</Citation><ArticleIdList><ArticleId IdType="pubmed">23483289</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Plant Sci. 2015 May 05;6:288</Citation><ArticleIdList><ArticleId IdType="pubmed">25999964</ArticleId></ArticleIdList></Reference><Reference><Citation>New Phytol. 2018 Oct;220(2):502-516</Citation><ArticleIdList><ArticleId IdType="pubmed">29992670</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2001 Jan 1;29(1):41-3</Citation><ArticleIdList><ArticleId IdType="pubmed">11125044</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Biotechnol. 2000 Jul;18(7):784-8</Citation><ArticleIdList><ArticleId IdType="pubmed">10888850</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Plant. 2015 Jul;8(7):998-1010</Citation><ArticleIdList><ArticleId IdType="pubmed">25620770</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Bioinformatics. 2010 Apr 01;11:165</Citation><ArticleIdList><ArticleId IdType="pubmed">20356413</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cells. 2011 May;31(5):447-54</Citation><ArticleIdList><ArticleId IdType="pubmed">21399993</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Plant Sci. 2018 Apr 04;9:399</Citation><ArticleIdList><ArticleId IdType="pubmed">29670638</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Cell Physiol. 2015 Feb;56(2):195-214</Citation><ArticleIdList><ArticleId IdType="pubmed">25294860</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Bioinformatics. 2014 Jun 12;15:182</Citation><ArticleIdList><ArticleId IdType="pubmed">24925680</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Sci. 2011 Dec;181(6):675-87</Citation><ArticleIdList><ArticleId IdType="pubmed">21958710</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Plant Sci. 2018 Sep 28;9:1427</Citation><ArticleIdList><ArticleId IdType="pubmed">30323825</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Cell. 2012 Aug;24(8):3393-405</Citation><ArticleIdList><ArticleId IdType="pubmed">22942381</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Plant Sci. 2016 Jul 14;7:1029</Citation><ArticleIdList><ArticleId IdType="pubmed">27471513</ArticleId></ArticleIdList></Reference><Reference><Citation>Biotechnol Biofuels. 2017 Nov 30;10:253</Citation><ArticleIdList><ArticleId IdType="pubmed">29213313</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Physiol. 2014 Apr;164(4):1952-66</Citation><ArticleIdList><ArticleId IdType="pubmed">24532604</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant J. 2011 Aug;67(3):499-512</Citation><ArticleIdList><ArticleId IdType="pubmed">21649762</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Genomics. 2017 Apr 17;18(1):300</Citation><ArticleIdList><ArticleId IdType="pubmed">28412928</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2017 Dec;7(1):42</Citation><ArticleIdList><ArticleId IdType="pubmed">28246387</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Cell. 2018 Jul;30(7):1645-1660</Citation><ArticleIdList><ArticleId IdType="pubmed">29891568</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Rev Biochem Mol Biol. 2014 May-Jun;49(3):212-41</Citation><ArticleIdList><ArticleId IdType="pubmed">24564339</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Cell. 2008 Jan;20(1):48-58</Citation><ArticleIdList><ArticleId IdType="pubmed">18203921</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Plant Sci. 2013 Oct 16;4:406</Citation><ArticleIdList><ArticleId IdType="pubmed">24137171</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Plant Sci. 2018 Dec 05;9:1669</Citation><ArticleIdList><ArticleId IdType="pubmed">30568662</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Genet. 2010 Apr;42(4):348-54</Citation><ArticleIdList><ArticleId IdType="pubmed">20208533</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Cell. 2008 Oct;20(10):2763-82</Citation><ArticleIdList><ArticleId IdType="pubmed">18952777</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Res. 2003 Nov;13(11):2498-504</Citation><ArticleIdList><ArticleId IdType="pubmed">14597658</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2014 May 23;4:5054</Citation><ArticleIdList><ArticleId IdType="pubmed">24852237</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Biol. 2005 Sep 6;15(17):1560-5</Citation><ArticleIdList><ArticleId IdType="pubmed">16139211</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2017 Jun 15;169(7):1177-1186</Citation><ArticleIdList><ArticleId IdType="pubmed">28622505</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2016 May 1;32(9):1423-6</Citation><ArticleIdList><ArticleId IdType="pubmed">27153000</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2011 Aug 1;27(15):2156-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21653522</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant J. 2009 Dec;60(6):1000-14</Citation><ArticleIdList><ArticleId IdType="pubmed">19737362</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Genet. 2015 Sep 21;11(9):e1005479</Citation><ArticleIdList><ArticleId IdType="pubmed">26390296</ArticleId></ArticleIdList></Reference><Reference><Citation>J Plant Physiol. 2017 Jun;213:1-15</Citation><ArticleIdList><ArticleId IdType="pubmed">28284108</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Plant Sci. 2012 Jun;17(6):332-40</Citation><ArticleIdList><ArticleId IdType="pubmed">22401845</ArticleId></ArticleIdList></Reference><Reference><Citation>Genet Epidemiol. 2014 Nov;38(7):610-21</Citation><ArticleIdList><ArticleId IdType="pubmed">25168954</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2005 Aug 15;21(16):3448-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15972284</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Bot. 2014 Oct;114(6):1099-107</Citation><ArticleIdList><ArticleId IdType="pubmed">24984711</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2367-72</Citation><ArticleIdList><ArticleId IdType="pubmed">24477691</ArticleId></ArticleIdList></Reference><Reference><Citation>Biotechnol Biofuels. 2012 Jan 04;5(1):2</Citation><ArticleIdList><ArticleId IdType="pubmed">22214220</ArticleId></ArticleIdList></Reference><Reference><Citation>Biotechnol Biofuels. 2012 Sep 21;5(1):71</Citation><ArticleIdList><ArticleId IdType="pubmed">22998926</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2013 Jan 1;29(1):15-21</Citation><ArticleIdList><ArticleId IdType="pubmed">23104886</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 1998;14(9):755-63</Citation><ArticleIdList><ArticleId IdType="pubmed">9918945</ArticleId></ArticleIdList></Reference><Reference><Citation>Planta. 2017 May;245(5):927-938</Citation><ArticleIdList><ArticleId IdType="pubmed">28083709</ArticleId></ArticleIdList></Reference><Reference><Citation>Genet Epidemiol. 2016 Jan;40(1):45-56</Citation><ArticleIdList><ArticleId IdType="pubmed">26626037</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2006 Sep 15;313(5793):1596-604</Citation><ArticleIdList><ArticleId IdType="pubmed">16973872</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1195-1200</Citation><ArticleIdList><ArticleId IdType="pubmed">28096391</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Physiol. 2018 Apr;176(4):2851-2870</Citation><ArticleIdList><ArticleId IdType="pubmed">29487121</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9722-E9729</Citation><ArticleIdList><ArticleId IdType="pubmed">29078399</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2012 Jan;40(Database issue):D290-301</Citation><ArticleIdList><ArticleId IdType="pubmed">22127870</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Cell Environ. 2014 May;37(5):1250-8</Citation><ArticleIdList><ArticleId IdType="pubmed">24237261</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Bot. 2015 Jun;115(7):1053-74</Citation><ArticleIdList><ArticleId IdType="pubmed">25878140</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Hum Genet. 2007 Sep;81(3):559-75</Citation><ArticleIdList><ArticleId IdType="pubmed">17701901</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2014 Apr 15;9(4):e95176</Citation><ArticleIdList><ArticleId IdType="pubmed">24736620</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2012 Jan;40(Database issue):D1178-86</Citation><ArticleIdList><ArticleId IdType="pubmed">22110026</ArticleId></ArticleIdList></Reference><Reference><Citation>Development. 2010 Oct;137(19):3153-65</Citation><ArticleIdList><ArticleId IdType="pubmed">20823061</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 2003 Sep 1;17(17):2088-93</Citation><ArticleIdList><ArticleId IdType="pubmed">12923061</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14732-7</Citation><ArticleIdList><ArticleId IdType="pubmed">11724959</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Genet. 2015 Feb 11;11(2):e1004980</Citation><ArticleIdList><ArticleId IdType="pubmed">25671434</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Plant Sci. 2013 Jun 11;4:189</Citation><ArticleIdList><ArticleId IdType="pubmed">23781226</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Physiol. 2010 Jun;153(2):590-602</Citation><ArticleIdList><ArticleId IdType="pubmed">20388664</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10848-53</Citation><ArticleIdList><ArticleId IdType="pubmed">23754401</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Plant Biol. 2011 Dec 01;11:173</Citation><ArticleIdList><ArticleId IdType="pubmed">22133261</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Genomics. 2015 Jan 23;16:24</Citation><ArticleIdList><ArticleId IdType="pubmed">25613058</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Plant Sci. 2016 Nov 24;7:1750</Citation><ArticleIdList><ArticleId IdType="pubmed">27933074</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2017 Jan 4;45(D1):D1040-D1045</Citation><ArticleIdList><ArticleId IdType="pubmed">27924042</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2012;7(3):e33034</Citation><ArticleIdList><ArticleId IdType="pubmed">22442676</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Biol Evol. 2009 Dec;26(12):2775-94</Citation><ArticleIdList><ArticleId IdType="pubmed">19734295</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Genomics. 2012 Jan 17;13:27</Citation><ArticleIdList><ArticleId IdType="pubmed">22251412</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Bot. 2015 Oct;66(20):6093-107</Citation><ArticleIdList><ArticleId IdType="pubmed">26160584</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Alabama</li><li>Californie</li><li>Maryland</li><li>Tennessee</li><li>Texas</li><li>Virginie-Occidentale</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Furches, Anna" sort="Furches, Anna" uniqKey="Furches A" first="Anna" last="Furches">Anna Furches</name></region><name sortKey="Chen, Jin Gui" sort="Chen, Jin Gui" uniqKey="Chen J" first="Jin-Gui" last="Chen">Jin-Gui Chen</name><name sortKey="Difazio, Stephen" sort="Difazio, Stephen" uniqKey="Difazio S" first="Stephen" last="Difazio">Stephen Difazio</name><name sortKey="Dixon, Richard A" sort="Dixon, Richard A" uniqKey="Dixon R" first="Richard A" last="Dixon">Richard A. 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